منابع مشابه
Thyroid Transcription Factor-1 (TTF-1): protein expression is not exclusive to lung and thyroid tissue
Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family, is a tissue specific transcription factor, and plays a role in regulating proteins expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sha...
متن کاملThyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung.
TTF-1 [thyroid transcription factor-1; also known as Nkx2.1, T/EBP (thyroid-specific-enhancer-binding protein) or TITF1] is a homeodomain-containing transcription factor essential for the morphogenesis and differentiation of the thyroid, lung and ventral forebrain. TTF-1 controls the expression of select genes in the thyroid, lung and the central nervous system. In the lung, TTF-1 controls the ...
متن کاملMapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1).
The phosphorylation of thyroid transcription factor-1 (TTF-1), is homeodomain-containing transcription factor that is required for thyroid-specific expression of the thyroglobulin and thyroperoxidase gene promoters, has been studied. Phosphorylation occurs on a maximum of seven serine residues that are distributed in three tryptic peptides. Mutant derivatives of TTF-1, with alanine sites, have ...
متن کاملThyroid transcription factor-1 (TTF1)
A strong, distinct nuclear staining reaction of type II pneumocytes, Clara cells and basal cells of the terminal bronchioles in the lung. A moderate to strong, distinct nuclear staining reaction of the columnar epithelial cells of the terminal bronchioles in the lung. A strong, distinct nuclear staining reaction of all follicular epithelial cells in the thyroid gland. A strong nuclear s...
متن کاملThyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.
Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) is a homeodomain-containing transcription factor essential for the morphogenesis and differentiation of the lung. In the lung, TTF-1 controls the expression of surfactant proteins that are essential for lung stability and lung host defense. In this study, we identified functionally important transcription factor binding sites in the TTF-1 prox...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACTA HISTOCHEMICA ET CYTOCHEMICA
سال: 1998
ISSN: 0044-5991,1347-5800
DOI: 10.1267/ahc.31.287